Engineering parathyroid cells to treat secondary hyperparathyroidism

Hyperparathyroidism due to parathyroid carcinoma.

Mast cells in parathyroid glands of hyperparathyroidism.

Parathyroid glands from cases of hyperparathyroidism have been examined with particular attention to mast cells. In ;normal' glands accompanying an adenoma they were common, although there was a wide range in their frequency, whereas in pathological tissue, both adenoma and hyperplasia, mast cells were scarce. This difference between glands was examined with respect to alterations in gland size...

Pedicled parathyroid gland autotransposition in secondary and tertiary hyperparathyroidism.

INTRODUCTION Symptomatic hyperparathyroidism (HPT) refractory to medical management requires surgical intervention with subtotal parathyroidectomy. Primary HPT commonly manifests as a parathyroid adenoma affecting a single gland and can be treated with excision of this single gland. However, secondary HPT in the setting of renal failure or familial diseases often presents with multiglandular hy...

Parathyroid calcification as a complication of secondary hyperparathyroidism.

Prem K.G. Chandran, MD, Iowa Methodist Medical Center, and Iowa Lutheran Hospital, 1215 Pleasant Suite 100, Des Moines, IA 50309 (USA) Dear Sir, Metabolic consequences of chronic irreversible renal failure include hyperphosphatemia, hypocalcemia, and secondary hyperparathyroidism. Persistent hyperphosphatemia not only contributes to abnormal vitamin D balance, but is also responsible for metast...

Parathyroid hormone between limits and possibilities in secondary hyperparathyroidism

Introduction Renal hyperparathyroidism is a major clinical problem resulting in elevated serum parathyroid hormone (PTH) levels. This condition is often called secondary hyperparathyroidism (SHPT), although the parathyroid cells changed their secretion of PTH from a secondary (reactive) pattern to a primary (autonomous) pattern. In the following sections, secondary hyperparathyroidism is used s...